Modified mRNA May Suppress Immune Activation at Multiple Steps of RIG-I Pathway
One major hurdle for biological therapies such as messenger RNA (mRNA) is the threat of immune activation. However, over the last decade, scientists have discovered that mRNA containing various modified nucleotides, such as pseudouridine and 5-methylcytidine, can suppress innate immune activation, making mRNA a powerful tool for regenerative medicine, treatment of diseases, and reprogramming of cells. Nevertheless, the detailed mechanisms of how the modified nucleotides evade immune activation are still largely unknown, particularly for lesser studied modified nucleotides.
Last month, researchers from Harvard and Rutgers University published work that sought to uncover the mechanisms that allow these modified nucleotides to evade immune activation through...